5-lipoxygenase: mechanisms of regulation.
Abstract
5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LT antagonists are used in treatment of asthma, more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged. Thus, understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.
| Authors: | Rådmark O, Samuelsson B. |
|---|---|
| Journal: | J Lipid Res. 50 Suppl:S40-5 |
| Year: | 2009 |
| PubMed: | Find in PubMed |