Restricted growth of ent- and tonB mutants of Salmonella enterica serovar Typhi in human Mono Mac 6 monocytic cells
Abstract
Monocytes and macrophages are an important host defense in humans infected with Salmonella enterica serovar Typhi. Bacterial ability to survive in these cells is therefore a crucial virulence characteristic of this pathogen. In this study, we demonstrate that growth of a Salmonella enterica serovar Typhi enterochelin synthesis mutant and a tonB mutant in the human monocyte cell line Mono Mac 6 is restricted compared to that of the parental wild-type Ty2 strain. These results suggest that enterochelin- and TonB-mediated iron uptake plays a role in S. enterica serovar Typhi pathogenesis, and also suggest that mutations in iron uptake may attenuate S. enterica serovar Typhi strains for human beings.
Authors: | Gorbacheva VY, Faundez G, Godfrey HP, Cabello FC |
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Journal: | FEMS Microbiol Lett 196: 7-11 |
Year: | 2001 |
PubMed: | Find in PubMed |