Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.

Abstract

BACKGROUND/OBJECTIVES: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection. METHODS: By using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure. RESULTS: We present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV. CONCLUSIONS: This model could be of interest for understanding in whole body the clinical alteration that persist despite ART.