Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms.
Abstract
Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. MDS shows reduced inflammatory activity in CD14+ cells, whereas CMML exhibits heightened inflammation, highlighting distinct disease mechanisms.
Authors: | Rimpa CM, Grigoriou M, Tasis A, Paschalidis N, Filia A, Vatsellas G, Papazoglou P, Chatzigeorgiou A, Kymparidou C, Papoutselis M, Misidou C, Spyropoulos T, Dimitriou D, Hatzikirou H, Liapis K, Lamprianidou E, Kotsianidis I, Mitroulis I, |
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Journal: | Eur J Immunol;2025 Jan;55(1):e202451387. doi:10.1002/eji.202451387 |
Year: | 2025 |
PubMed: | PMID: 39513195 (Go to PubMed) |