Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock


Characteristics of blood immune cell profile and their correlation with disease progression in patients infected with HIV-1.


BACKGROUND: Antiretroviral therapy (ART) can reduce viral load in individuals infected with human immunodeficiency virus (HIV); however, some HIV-infected individuals still cannot achieve optimal immune recovery even after ART. Hence, we described the profile of peripheral immune cells and explored the association with disease progression in patients infected with HIV-1. METHODS: Mass cytometry analysis was used to characterize the circulating immune cells of 20 treatment-naive (TNs), 20 immunological non-responders (INRs), 20 immunological responders (IRs), and 10 healthy controls (HCs). Correlation analysis was conducted between cell subpopulation percentages and indicators including HIV-1 cell-associated (CA)-RNA, DNA, CD4+ T cell count, and CD4/CD8 ratio. RESULTS: Global activation, immunosenescence, and exhaustion phenotypes were observed in myeloid cells and T cells from individuals with HIV-1 infection. We also found that specific subsets or clusters of myeloid, CD4+ T, and CD8+ T cells were significantly lost or increased in TN individuals, which could be partially restored after receiving ART. The percentages of several subpopulations correlated with HIV-1 CA-RNA, DNA, CD4+ T cell count, and CD4/CD8 ratio, suggesting that changes in immune cell composition were associated with therapeutic efficacy. CONCLUSION: These data provide a complete profile of immune cell subpopulations or clusters that are associated with disease progression during chronic HIV-1 infection, which will improve understanding regarding the mechanism of incomplete immune recovery in INRs.

Authors: Guo XY, Qu MM, Wang X, Wang ZR, Song JW, Yang BP, Guo YT, Zhang Y, Zhang C, Fan X, Xu W, Xu R, Zhang JY, Chen SY, Jiao YM, Sun LJ, Wang FS,
Journal: BMC Infect Dis;2023Dec20; 23 (1) 893. doi:10.1186/s12879-023-08847-z
Year: 2023
PubMed: PMID: 38124099 (Go to PubMed)