Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds
Abstract
The involvement of cytochrome-P450-dependent metabolism of small-molecular-weight compounds as a prerequisite for an optimal lymphocyte response to those compounds is discussed on the basis of studies with compound such as p-phenylenediamine, sulfamethoxazole, chloramphenicol and fragrances. Subsequently, data on cytochrome P450 activity and CYP gene expression in monocytes and MAC-6 cells for cytochromes P450 2E1 and 3A4 are presented.
| Authors: | Merk, H.F., Baron, J., Hertl, M., Niederau, D., Rübben, A. |
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| Journal: | Int. Arch. Allergy Immunol. 113: 173-176 |
| Year: | 1997 |
| PubMed: | Find in PubMed |