Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock


COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.


We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.

Authors: Schrijver IT, Théroude C, Antonakos N, Regina J, Le Roy D, Bart PA, Chiche JD, Perreau M, Pantaleo G, Calandra T, Roger T,
Journal: Eur J Immunol;2022Jun10. doi:10.1002/eji.202249827
Year: 2022
PubMed: PMID: 35689332 (Go to PubMed)