Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Distribution of monocytes subpopulations in the peripheral blood from patients with Behcet's disease - Impact of disease status and colchicine use.

Abstract

The innate immune response has a predominant role in Behcet's disease (BD) pathogenesis, but few studies have assessed monocytes in BD. This study aims to evaluate the profile of monocytes subsets in the peripheral blood of BD patients and healthy controls (HC). Monocytes subsets were identified as classical (CD14+CD16-), intermediate (CD14+CD16dim), and non-classical (CD14dimCD16high) subsets. Patients with BD presented a lower number of total monocytes (p = 0.020) and a lower number (p < 0.0001) of circulating classical monocytes than HC. In contrast, the number of intermediate monocytes was higher in BD patients than HC (p < 0.0001). In BD patients, no associations were observed with the severity of clinical manifestations or therapy. Colchicine was associated with a higher number of non-classical monocytes (p = 0.035). In conclusion, BD patients present an altered distribution of monocytes subsets with a reduction of classical and an increase of intermediate subsets.

Authors: Gazzito Del Padre TC, Belem JMFM, de Aguiar MF, Torquato HFV, Paredes EJG, Abdulahad WH, Brouwer E, de Souza AWS,
Journal: Clin Immunol;2021Sep13 108854. doi:10.1016/j.clim.2021.108854
Year: 2021
PubMed: PMID: 34530137 (Go to PubMed)