Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Comprehensive phenotyping of human dendritic cells and monocytes.

Abstract

Professional antigen-presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T cell responses. Recent technological developments in single-cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue-specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine-grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system. This article is protected by copyright. All rights reserved.

Authors: Mair F, Liechti T,
Journal: Cytometry A; 2021 Mar;99(3):231-242.
Year: 2021
PubMed: PMID: 33200508 (Go to PubMed)