Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Comprehensive phenotyping of human dendritic cells and monocytes.

Abstract

Professional antigen-presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T cell responses. Recent technological developments in single-cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue-specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine-grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system. This article is protected by copyright. All rights reserved.