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Decrease of Non-Classical and Intermediate Monocyte Subsets in Severe Acute SARS-CoV-2 Infection.

Abstract

In patients with severe SARS-CoV-2 infection, the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non-classical (NC) and intermediate (INT) monocytes are known to be involved during viral and bacterial infections. In this study, 30 patients with different manifestations of acute SARS-CoV-2 infection were investigated with a flow cytometric study of NC, INT, and classical (CL) monocytes. Significantly reduced NC and INT monocytes and a downregulated HLA-DR were found in acute patients with severe SARS-CoV-2 symptoms. Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. 2020 International Society for Advancement of Cytometry.

Authors: Gatti A, Radrizzani D, ViganĂ² P, Mazzone A, Brando B,
Journal: Cytometry A; 2020 09 ; 97 (9) 887-890. doi:10.1002/cyto.a.24188
Year: 2020
PubMed: PMID: 32654350 (Go to PubMed)