Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Prognostic value of monocyte subset distribution in chronic myelomonocytic leukemia: results of a multicenter study.

Abstract

To the Editor: According to the World Health Organization (WHO) classification, chronic myelomonocytic leukemia (CMML) diagnosis requires both a persistent peripheral blood monocyte count >1 × 109/L and monocytes accounting for ≥10% of the total white blood cell count (WBC) [1]. We and others have shown that a relative increase in the classical monocyte fraction (cMo; CD14++CD16−) ≥94% of total peripheral blood monocytes, as measured by flow cytometry, rapidly distinguishes a CMML from other causes of monocytosis, mostly reactive monocytosis, with high specificity and sensitivity [2–6].

Authors: Jestin M, Tarfi S, Duchmann M, Badaoui B, Freynet N, Tran Quang V, Sloma I, Droin N, Morabito M, Leclerc M, Maury S, Fenaux P, Solary E, Selimoglu-Buet D, Wagner-Ballon O, Groupe Francophone des Myélodysplasies (GFM),
Journal: Leukemia; 2020 Jul 20 . doi:10.1038/s41375-020-0955-1
Year: 2020
PubMed: PMID: 32684630 (Go to PubMed)