Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.
|Authors:||Vita S, Zuccalà P, Savinelli S, Mascia C, Rossi R, Schiavone F, Marocco R, Tieghi T, Iannetta M, Nijhawan P, Zingaropoli MA, d'Ettore G, Vullo V, Mastroianni CM, Lichtner M,|
|Journal:||J Immunol Res; 2020 ; 2020 2781350. doi:10.1155/2020/2781350|
|PubMed:||PMID: 32258171 (Go to PubMed)|