Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.
Abstract
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.
| Authors: | Vita S, Zuccalà P, Savinelli S, Mascia C, Rossi R, Schiavone F, Marocco R, Tieghi T, Iannetta M, Nijhawan P, Zingaropoli MA, d'Ettore G, Vullo V, Mastroianni CM, Lichtner M, |
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| Journal: | J Immunol Res; 2020 ; 2020 2781350. doi:10.1155/2020/2781350 |
| Year: | 2020 |
| PubMed: | PMID: 32258171 (Go to PubMed) |