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Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.

Abstract

Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.

Authors: Vita S, ZuccalĂ  P, Savinelli S, Mascia C, Rossi R, Schiavone F, Marocco R, Tieghi T, Iannetta M, Nijhawan P, Zingaropoli MA, d'Ettore G, Vullo V, Mastroianni CM, Lichtner M,
Journal: J Immunol Res; 2020 ; 2020 2781350. doi:10.1155/2020/2781350
Year: 2020
PubMed: PMID: 32258171 (Go to PubMed)