Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis.

Abstract

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP.

Authors: Hamatani M, Yamashita H, Ochi H, Ashida S, Hashi Y, Okada Y, Fujii C, Kawamura K, Kitazawa R, Nakagawa M, Mizuno T, Takahashi R, Kondo T,
Journal: Neurobiol. Dis.; 2020 Apr 07 104867. doi:10.1016/j.nbd.2020.104867
Year: 2020
PubMed: PMID: 32276111 (Go to PubMed)