Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Altered Monocyte Subsets in Patients with Chronic Idiopathic Neutropenia.

Abstract

To the editor, Chronic idiopathic neutropenia (CIN) of adults is a neutrophil disorder characterized by the persistent and unexplained reduction in the number of peripheral blood (PB) neutrophils below the lower limit of the normal range in a given ethnic population, for a prolonged period (more than 3 months) [1]. The diagnosis of CIN is based on exclusion criteria, namely the absence of clinical and laboratory evidence of any underlying disease that might be associated with neutropenia, absence of history of exposure to irradiation, absence of use of chemical compounds or intake of drugs that might cause neutropenia, negative antineutrophil antibody testing to exclude antibody-mediated immune neutropenia, and normal bone marrow (BM) morphology and karyotype to exclude cases of myelodysplastic syndrome (MDS) presenting as isolated neutropenia [1]. The inclusion in the diagnostic algorithm of a detailed flow cytometric analysis of the BM progenitor cells and next generation sequencing of genes related to myeloid malignancies largely contributes to the recognition of pre- MDS neutropenic patients [1, 2].