Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Monocyte subsets and monocyte-platelet aggregates: implications in predicting septic mortality among surgical critical illness patients.

Abstract

BACKGROUND: Monocyte subsets and monocyte-platelet aggregates (MPAs) play important roles in inflammation. AIM: To evaluate the association between the three human monocyte subsets and their contributions to MPAs and mortality among septic patients. METHODS: Consecutive septic patients were enrolled in. Age- and gender-matched nonseptic patients were recruited as control patients. Monocyte subsets and monocyte-platelet aggregates were determined by flow cytometric analysis. RESULTS: Elevated percentage of MPAs (MPAs%) was associated with an increased risk of mortality. CONCLUSIONS: This study demonstrated increased MPAs% enables the identification of a group of septic patients at high risk of death.