Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Longitudinal Monocyte Subset Dynamics as Biomarker in Adult Histiocytosis: Association With Mutational Status, Kinase Inhibitor Exposure and Relapse Risk.

Abstract

Histiocytoses are clonal disorders driven by pathological activation of the mitogen‐activated protein kinase (MAPK) pathway (including BRAF, MAP2K1, KRAS, NRAS) within CD68+ histiocytes [1]. These conditions involve a complex interplay of clonal signals, immune responses, and inflammatory microenvironments. Clinical and radiological presentation are highly heterogenous depending on the histiocytosis type and mutational status. Despite significant therapeutic advances, relapses remain a challenge, particularly during treatment tapering or discontinuation [2, 3]. Recent studies underscore the critical role of monocytes in histiocytosis [4, 5].