Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

CD38+ monocytes fuel fibrosis in myeloproliferative neoplasm.

Abstract

In this issue of Blood, Yan et al 1 have identified and characterized a unique subset of proinflammatory monocytes, in both murine models of myelofi- brosis (MF) and human MF samples. These cells exhibited increased expression of CD38, a transmembrane hydrolase that converts NAD + to nicotinamide and ADP ribose. Increased CD38 expression in these mono- cytes resulted in depletion of NAD + , resulting in metabolic rewiring which ultimately induces fibrosis through increased NF-κB signaling and tumor necrosis factor-alpha (TNF-α) secretion.