Application of Mendelian Randomization Analysis on the Exploration of the Association Between Immune Cell Phenotypes and Alzheimer's disease.
Abstract
INTRODUCTION: This study explores the correlation between immune inflammation and Alzheimer's disease (AD), focusing on immune-brain interactions impacting neurodevelopment and function. METHODS: Public genetic data were used to analyze 731 immune cell signals, employing two-sample Mendelian randomization, with multiple testing corrected by the Bonferroni-adjusted false discovery rate (FDR). RESULTS: Six immune phenotypes were identified as significantly increasing AD risk (effect sizes ranging from OR=1.038 to 1.123), including HLA DR on CD33+ HLA DR+ CD14-, HLA DR on CD14+ monocyte, CD4+ CD8dim T cells (% lymphocytes), CD33 on HLA DR on CD14+ CD16- monocyte, CD33 on CD33+ HLA-DR+ CD14dim cells and CD11c on CD62L+ myeloid dendritic cell. CONCLUSION: This study confirms the genetic association between specific immune cells and AD, highlighting potential immune-related biomarkers for AD risk.
| Authors: | Guo J, Zhang H, Geng Z, Dai N, Fu B, Kong QX, Fu X, |
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| Journal: | J Nerv Ment Dis;2025Sep16. doi:10.1097/NMD.0000000000001851 |
| Year: | 2025 |
| PubMed: | PMID: 40955699 (Go to PubMed) |