Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

MAPK-kinase mutations and aortic lesions are associated with distribution of circulating monocytes in histiocytosis.

Abstract

Histiocytosis represents a spectrum of rare myeloid neo- plasms characterized by the accumulation and proliferation of CD68+ histiocytes, derived from the “monocyte/macro- phage system,” within organs.1 These histiocytes, along with other inflammatory cells, contribute to disease symptoms. Recent research has underlined the major role of mono- cytes in the pathogenesis of histiocytosis.2,3 Moreover, a specific monocyte subset distribution has been identified in histiocytosis, which is distinct from that in other my- eloid neoplasms, and is associated with vascular lesions.4 To characterize the impact of the clonal environment, the inflammatory syndrome, and vascular lesions on the distri- bution of monocyte subsets in histiocytosis, we compared this monocyte distribution in adult histiocytosis, giant cell arteritis (GCA), a vasculitis with an inflammatory pattern and frequent aortic lesions,5 and healthy donors.