Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Single-cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation.

Abstract

Dear Editor, Since colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death globally,1,2 we want to explore non-invasive early diagnosis methods and find some supplements to colonoscopy. In this study, we for the first time performed peripheral blood mononuclear cell (PBMC) transcriptome analysis of healthy individuals, colon adenoma patients and colon adenocarcinoma patients using single-cell RNA sequencing, and focused on peripheral circulating monocytes changing fromhealthy people to adenoma patients to carcinoma patients.