Adsorptive cytapheresis for ulcerative colitis with focus on removing platelets and platelet-aggregates.
Abstract
INTRODUCTION: Platelet abnormalities and secondary thrombocytosis are clinical features of ulcerative colitis (UC) and seem to play a relevant role in pathogenesis. This work analyzed the adsorption characteristics of the adsorber Immunopure. METHODS: A prospective study was performed to investigate the module in vitro with blood from healthy donors in a down-scaled recirculation model and in vivo in six patients suffering from UC. Furthermore, adsorber beads were investigated by immunofluorescence analyses. Apheresis was performed over 5 weeks at weekly intervals. RESULTS: In vitro as well as in vivo, the module showed a strong adsorption of platelets, monocytes, CD14+ CD16+ monocytes, neutrophils, and platelet leukocyte aggregates (PLAs). Five of the six patients benefited from the treatment (83%), and four (67%) went into remission. On average, the CAI was reduced by 6.4 points. CONCLUSION: Immunopure treatments improved the course of the disease and were well tolerated. The module strongly adsorbs platelets and platelet-aggregates.
| Authors: | Schneider M, Waitz G, Prophet H, Schober HC, Ramlow W, |
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| Journal: | Ther Apher Dial;2022Oct23. doi:10.1111/1744-9987.13942 |
| Year: | 2022 |
| PubMed: | PMID: 36273320 (Go to PubMed) |