Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction.
Abstract
Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naive HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naive patients and healthy subjects. Intensity of C-C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.
| Authors: | Dentone C, Fenoglio D, Parodi A, Altosole T, Di Biagio A, Bozzano F, Nasi G, Vena A, Fabbi M, Ferrera F, Bruzzone B, Giacomini M, Giacobbe DR, Pelosi P, De Maria A, Bassetti M, De Palma R, Filaci G, |
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| Journal: | Clin Exp Med;2022 Nov 13;1-8. doi:10.1007/s10238-022-00927-9 |
| Year: | 2022 |
| PubMed: | PMID: 36372857 (Go to PubMed) |