Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Human dendritic cell subset 4 (DC4) correlates to a subset of CD14dim/-CD16++ monocytes.

Abstract

To the Editor: Knowledge about the origin, tissue fate, and precise functions of circulating monocytes and dendritic cells (DCs) in human subjects is still incomplete and requires elucidation. Advances made in the last years have established unequivocally that blood monocytes and DCs are phenotypically Lin2HLA-DR1 because they express HLA-DR molecules but not lymphocyte lineage markers.1,2 Moreover, based on their CD14 versus CD16 expression, monocytes have been recognized to cluster into 3 subsets known as classical CD1411CD162, intermediate CD141CD161, and nonclassical CD14dim/2CD1611 monocytes,1 with the latter including CD14dim/2CD1611slan1 monocytes as major components.1,2