Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Correlation between CD14+CD16++ monocytes in peripheral blood and hypertriglyceridemia after allograft renal transplantation.

Abstract

BACKGROUND: Cardio-cerebrovascular diseases are key factors causing recipient the death after kidney transplantation (KT). Hypertriglyceridemia (HTG), a complication commonly occurring among KT patients, is a major risk factor for cardio-cerebrovascular diseases. The objective of this study was to examine the correlation between peripheral CD14+CD16++ monocytes in KT patients and blood lipids as well as factors affecting hyperglycemia, seeking to understand mechanisms of inflammatory immune reactions. METHODS: KT patients (n = 60) were divided into subjects with HTG (n = 35) versus without HTG (n = 25). A cohort of healthy participants (55 cases) was divided into the cases without (n = 30) versus with HTG (n = 25). The proportion of peripheral CD14+CD16 ++ monocytes was determined using flow cytometry and hematology, and biochemical indicators were measured by conventional methods. We correlated HTG with these indicators. RESULTS: The proportion of peripheral blood CD14+CD16++ monocytes among the renal transplant group was significantly lower (P < .05) than that of normal controls. The expression of CD14+CD16++ monocytes among transplant recipients positively correlated with triglycerides (R = 0.449 and R = 0.008, respectively). CONCLUSION: CD14+CD16++ mononcytes in peripheral blood may represent an independent risk factor for HTG after KT.