Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock


Comprehensive immune cell profiling depicts an early immune response associated with severe COVID-19 disease in cancer patients.


Recent studies have highlighted multiple immune perturbations related to SARS-CoV-2 infection-associated respiratory disease (COVID-19). Some of them were associated with immunopathogenesis of the severe COVID-19. However, the reports on immunological indicators of severe COVID-19 in the early phase of infection in patients with comorbidities like cancer are scarce. We prospectively studied ~200 immune response parameters, including a comprehensive immune-cell profile, inflammatory cytokines, and other parameters in 95 patients with COVID-19 (37 cancer patients without active disease and intensive chemo/immunotherapy, 58 patients without cancer) and 21 healthy donors. Of 95 patients, 41 had severe disease, and the remaining 54 were categorized into non-severe disease. We evaluated the association of immune response parameters with severe COVID-19. By principal component analysis, three immune signatures defining characteristic immune response in COVID-19 patients were found. Immune cell perturbations, in particular, decreased levels of circulating dendritic cells (DC) along with reduced levels of CD4 T-cell subsets such as regulatory T cells (Tregs), Th1, Th9 and relative expansion of effector NK cells were significantly associated with severe-COVID-19. Compared to patients without cancer, the levels of terminal effector-CD4 T, Tregs, Th9, effector NK cells, B cells, intermediate-type monocytes, and myeloid-DC were significantly lower in cancer patients with mild and severe COVID-19. We concluded that severely depleted circulating myeloid-DCs and helper-T-subsets in the initial phase of infection were strongly associated with the severe COVID-19 independent of age, type of comorbidity and other parameters. Thus, our study describes the early immune response associated with severe COVID-19 disease in cancer patients without intensive chemo/immunotherapy.

Authors: Tembhare PR, Sriram HN, Chatterjee G, Khanka T, Gokarn A, Mirgh S, Rajendra A, Chaturvedi A, Ghogale SG, Deshpande N, Girase K, Dalvi K, Rajpal S, Patkar N, Trivedi B, Joshi A, Murthy V, Shetty N, Nair S, More A, Kamtalwar S, Chavan P, Bhat V, Bhat P, Sub
Journal: Immunol Cell Biol;2022 Jan;100(1):61-73 doi:10.1111/imcb.12504
Year: 2022
PubMed: PMID: 34582592 (Go to PubMed)