Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type.
To identify biomarkers for multiple system atrophy-cerebellar type (MSA-C), we used flow cytometry to measure surface marker expression of peripheral blood monocytes from patients with MSA-C or hereditary spinocerebellar degeneration (hSCD) and from healthy controls (HCs). The percentage of intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs and showed significant positive correlations with disease duration and unified MSA rating scale scores. The percentage of CD62L+ intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs. Early decrease of peripheral blood intermediate monocytes is characteristic of MSA-C and is a biomarker.
|Authors:||Matsuse D, Yamasaki R, Maimaitijiang G, Yamaguchi H, Masaki K, Isobe N, Matsushita T, Kira JI,|
|Journal:||J. Neuroimmunol.; 2020 Sep 20 ; 349 577395. doi:10.1016/j.jneuroim.2020.577395|
|PubMed:||PMID: 32977251 (Go to PubMed)|